• 11 FEB 16
    • 0

    Agreement of treatment effects for mortality from routinely meta-epidemiological survey

    Research from the BMJ which argues that RCD studies systematically and substantially overestimate mortality benefits of medical treatments compared with subsequent trials investigating the same question.  Observational RCD studies might not necessarily provide very reliable answers on how to best treat patients; caution is needed to prevent misguided clinical decision making

    If no randomized trials exist, clinicians and funders of care should consider that treatment effects are probably more uncertain and substantially smaller than RCD studies suggest; decisions for widespread adoption and reimbursement of expensive interventions might be best withheld until trial evidence becomes available

    Agreement of treatment effects for mortality from routinely meta-epidemiological survey, Lars G Hemkens,1,2 Despina G Contopoulos-Ioannidis,3,4 John P A Ioannidis1,4-6

    BMJ 2016;352:i493  http://dx.doi.org/10.1136/bmj.i493

     

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